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Supplementary Methods and Legends

Ig gene rearrangement by Ig complementarity determinig region 3 (CDR3) spectratyping . Total RNA was extracted using RNeasy Minikit (Quiagen) or Nucleo Spin-RNA/protein (Macherey-Nagel) columns and was retrotranscribed with Advantage RT for PCR kit (Clontech). cDNA was amplified with the following fast performance liquid chromatography (FPLC) purified primers (Invitrogen): mu1 forward (FW), CAG...

Hippocratic lives and legends

ascribed to Soranus and others. He repeatedly states reservations about how far these can be believed, but just as often rescues himself from serious doubt by appealing to an argument from plausibility. So far as the Corpus itself goes, it is not that we have Hippocrates at its centre, but rather, in the more frequent softer formulation, the work of Hippocrates and his circle-though again Jouan...

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Myths and Legends in Learning

This paper is a discussion of machine learning theory on empirically learning classification rules. The paper proposes six myths in the machine learning community that address issues of bias, learning as search, computational learning theory, Occam’s razor, “universal” learning algorithms, and interactive learning. Some of the problems raised are also nddrcssed from a Bayesian perspective. The ...

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